Menstrual Migraines

Menstrual migraines are headaches that occur around the time of a woman's period, often triggered by hormonal changes—specifically, the drop in estrogen just before menstruation begins. These migraines can be more severe, longer-lasting, and harder to treat than other types of headaches. Symptoms may include throbbing pain (often on one side of the head), nausea, sensitivity to light and sound, and fatigue. Some women experience them regularly, either only during their menstrual cycle or along with other migraine episodes throughout the month. Treatment may include hormonal therapies, preventive medications, or acute migraine relief strategies.

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  • Testing new oral medications to help prevent menstrual migraines

  • Focuses on reducing migraines that happen around your period

  • Pills are taken for a few days each month before the start of a period

  • The study lasts several months with regular check-ins

About this Study

Who is it for?

Women 18 years or older

Have regular monthly periods

Get migraines around the time of their period (at least 2 of the last 3 cycles)

Have fewer than 15 headache days per month

Not taking daily migraine prevention medication

Benefits for participants

Get free study medication and care

May experience fewer and less severe migraines

Regular check-ins with friendly research staff

May receive reimbursement for time and travel

Help improve future migraine treatments for women








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